The scientific targets: the myocardium, the vasculature and the body’s response to heart failure
Published: March 28 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Heart failure (HF) is a common but complex clinical syndrome associated with a reduced ability of a heart to pump and/or fill with blood. We now appreciate the more complex picture involving metabolic derangements, changes in fetal gene expression and abnormalities in the periphery as forming part of the HF syndrome. Therapeutic targets include the failing myocardium, the vasculature and peripheral mechanisms. The pathophysiology of HF is currently being intensively investigated, with the identification of new relevant mechanisms, some of them emerging as potential therapeutic targets.
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The scientific targets: the myocardium, the vasculature and the body’s response to heart failure. (2024). Global Cardiology, 2(1). https://doi.org/10.4081/cardio.2024.19
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