Letters to the Editor
31 July 2025

Self-administered intranasal etripamil: a breakthrough in PSVT first-line treatment

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Dear Editor, 

PSVT, AVRT, and AVNRT are types of arrhythmia resulting from disruptions in the heart's electrical activity, originating from the sinoatrial node and propagating via the atria to the AV node, causing sudden symptoms like palpitations and dyspnea...

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Citations

1. Ferguson JD, DiMarco JP. Contemporary management of paroxysmal supraventricular tachycardia. Circulation 2003;107:1096–9. DOI: https://doi.org/10.1161/01.CIR.0000059743.36226.E8
2. Chu GS, Gupta D. Update on etripamil nasal spray for the at-home treatment of acute paroxysmal supraventricular tachycardia. Heart Int 2021;15:2-6. DOI: https://doi.org/10.17925/HI.2021.15.1.2
3. Stambler BS, Plat F, Sager PT, et al. First randomized, multicenter, placebo-controlled study of self-administered intranasal etripamil for acute conversion of spontaneous paroxysmal supraventricular tachycardia (NODE-301). Circ Arrhythm Electrophysiol 2022;15: e010915. DOI: https://doi.org/10.1161/CIRCEP.122.010915
4. Camm AJ, Ip JE, Coutu B, et al. Quality of life measures with etripamil self-administration for acute episodes of paroxysmal supraventricular tachycardia in a medically unsupervised setting: patient-reported outcomes from NODE-303. Eur Heart J 2024;45:ehae666. DOI: https://doi.org/10.1093/eurheartj/ehae666.631
5. Queiroz I, Barbosa L, Defante MLR, et al. Abstract 4137870: Nasal etripamil spray efficacy for acute paroxysmal supraventricular tachycardia: a systematic review, meta-analysis and trial sequential analysis. Circulation 2024;150. DOI: https://doi.org/10.1161/circ.150.suppl_1.4137870

How to Cite



1.
Khalid M, Asif A, Rasheed S. Self-administered intranasal etripamil: a breakthrough in PSVT first-line treatment . Global Cardiol [Internet]. 2025 Jul. 31 [cited 2025 Aug. 5];. Available from: https://www.globalcardiology.info/site/article/view/79