Articles
31 December 2025
Vol. 3 No. 4 (2025)
https://doi.org/10.4081/cardio.2025.90

Dyslipidemia and stroke-related mortality in the United States: a nationwide analysis for 2010-2020

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Heart failure, insulin resistance, metformin, empagliflozin, global longitudinal strain
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Authors

Muhammad Muneeb Ur Rehman
muneebqazi264@gmail.com
Shifa College of Medicine, Shifa International Hospital, Islamabad, Pakistan.
Iliyan Mithani
Baylor Scott and White Research Institute, Dallas, TX, United States.
Muhammad Sameer Arshad
Baylor Scott and White Research Institute, Dallas, TX, United States.
Syed Raza Shah
Department of Cardiology, University of Louisville, Louisville, KY, United States.
Wolfram Doehner
Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin; Deutsches Herzzentrum der Charité, Department of Cardiology-Campus Virchow, Charité Universitätsmedizin Berlin; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany.
Anandita Kulkarni
Baylor Scott and White Research Institute, Dallas, TX; Baylor Scott and White Health, The Heart Hospital, Plano, TX, United States.

Dyslipidemias are a significant risk factor for stroke. Still, there is limited data on mortality trends where both dyslipidemia and stroke are either contributing or underlying causes of death among adults aged ≥ 25 years. We aimed to evaluate the demographic, regional, and temporal trends in dyslipidemia and stroke-related mortality among adults from 2010 to 2020. The CDC WONDER mortality data were utilized to identify deaths with both dyslipidemia and stroke as either underlying or contributing causes of death in adults aged ≥ 25 years. Age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC) were calculated and further categorized by year, sex, race/ethnicity, region, and urban-rural status. Joinpoint regression was used to determine changes in trends over time. Between 2010 and 2020, a total of 106,813 dyslipidemia and stroke-related deaths occurred among adults aged ≥ 25 years, with the most in medical facilities (35.7%), at home (27.7%), or in nursing/long-term care facilities (26.9%). The AAMR increased from 3.47 in 2010 to 5.47 in 2020, stable through 2018 (APC 1.6 [95% CI, −0.4 to 2.7]) then rising sharply (APC 15.1 [95% CI, 7.5 to 19.5]). Men had higher mortality than women (AAMR: 4.44 vs. 3.66). The Non-Hispanic (NH) Black or African American population had the highest overall AAMR (4.97), followed by the NH White population (3.99), the NH American Indian or Alaska Native population (3.87), the NH Asian or Pacific Islander population (3.59), and the Hispanic or Latino population (3.25) Vermont (10.15) and Georgia (1.99) had the highest and lowest state-level rates, respectively. Regionally, the West (4.61) exceeded the Northeast (3.43). Nonmetropolitan areas (4.81) had consistently higher mortality than metropolitan areas (3.85). Dyslipidemia and stroke-related mortality increased significantly after a period of stability. The highest AAMRs were observed in men, NH Black individuals, and people living in the Western US and nonmetropolitan areas. Effective policies are required to reduce these mortality rates and improve cardiovascular health.

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How to Cite



1.
Rehman MMU, Mithani I, Arshad MS, Shah SR, Doehner W, Kulkarni A. Dyslipidemia and stroke-related mortality in the United States: a nationwide analysis for 2010-2020. Global Cardiol [Internet]. 2025 Dec. 31 [cited 2026 Jan. 18];3(4). Available from: https://www.globalcardiology.info/site/article/view/90
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