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Global Cardiology

eISSN 2975-2728

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Editor-in-Chief: Andrew J.S. Coats, Australia

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  • Applicability of obesity clinical practice guidelines in low- and middle-income countries

    Shelley Zieroth, Fausto Pinto, Stefan D. Anker, William T. Abraham, John J. Atherton, Javed Butler, Vijay Chopra, Andrew J.S. Coats, Martha Gulati, Tammy L. Kindel, José Luis Zamorano, Yuhui Zhang, Linong Ji, Yann Colardelle, Richard B. Weiskopf
    2025-06-30
    https://doi.org/10.4081/cardio.2025.77
    1108
    PDF: 562
    Appendix: 141
    HTML: 17
  • The Global Implementation Guidelines Initiative: how to optimize cardio-renal-metabolic care worldwide

    Fausto J. Pinto, Stefan D. Anker, William T. Abraham, John J. Atherton, Javed Butler, Vijay Chopra, Andrew J.S. Coats, Yann Colardelle, Maria Rosa Costanzo, Veronica Dean, Gerasimos Filippatos, Martha Gulati, Julio Rosenstock, John Teerlink, Subodh Verma, Jose Luis Zamorano, Yuhui Zhang, Shelley Zieroth
    2025-04-16
    https://doi.org/10.4081/cardio.2025.68
    3361
    PDF: 528
    Appendix: 388
    HTML: 26
  • iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on prevention and treatment of cardiometabolic disease

    Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J.S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuanlin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss Quintana, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed , Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano Ruiz, Nandini Chatterjee, Vijay Chopra, Marc-André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M.C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Yuhui Zhang, Martha Gulati, Naveed Sattar, José Luis Zamorano
    2025-09-30
    https://doi.org/10.4081/cardio.2025.86
    1054
    PDF: 28
    Supplementary: 316
    Appendix: 262
  • Neck-to-height ratio in Bosnian university students according to the 2017 American College of Cardiology/American Heart Association guidelines on hypertension classification

    Asija Začiragić, Marija Mikić, Amela Dervišević, Orhan Lepara, Nesina Avdagić, Nermina Babić, Almir Fajkić, Amina Valjevac
    2024-03-28
    https://doi.org/10.4081/cardio.2024.27
    1890
    PDF: 220
    HTML: 12
  • Coronary artery calcium scoring. What clinicians need to know

    Syeda Sundus Shah Bokharii, Cristiana Vitale, Eman Khan, Giuseppe M.C. Rosano, Laibah Arshad Khan
    2025-12-11
    https://doi.org/10.4081/cardio.2025.87
    322
    PDF: 160
    HTML: 1
  • Lipoprotein(a): what clinicians need to know

    Laibah Arshad Khan, Muhammad Hanif, Ahmed Mustafa Rashid
    2025-09-01
    https://doi.org/10.4081/cardio.2025.80
    310
    PDF: 660
    HTML: 23
  • New left ventricular thrombus and embolic events in left ventricular dysfunction postmyocardial infarction

    Ali A. Youssef, Shaima Al-Omani, Mustafa A. Alrefae, Ahmad Suliman, Reem Hassan, Omar Saleh, Zizi S. Khalifa
    2024-11-05
    https://doi.org/10.4081/cardio.2024.43
    1898
    PDF: 679
    HTML: 3
  • Bridging the gap: integrating stress echocardiography, iFR, CFR, and FFR in the evaluation of coronary artery disease

    Konstantinos Stamos, Theodora Delaporta, Antonios Delaportas
    2025-04-16
    https://doi.org/10.4081/cardio.2025.66
    1288
    PDF: 273
    HTML: 0
  • iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025

    Vijay Chopra, Muhammad Shahzeb Khan, Magdy Abdelhamid, William T. Abraham, Offer Amir, Stefan D. Anker, John J. Atherton, Fernando Bacal, Ralph Stephan von Bardeleben, Dulce Brito, Lucrecia Maria Burgos, Javed Butler, Maria Rosa Costanzo, Albertino Damasceno, Justin A. Ezekowitz, Ishaque Hameed, Sivadasanpillai Harikrishnan, Tiny Jaarsma, Anuradha Lala, Ileana L. Piña, Clara Saldarriaga, David Sim, John R. Teerlink, Nqoba Tsabedze, Hiroyuki Tsutsui, Jing Yu, Yuhui Zhang, Mohammad Zubaid, Nikhil Balankhe, Juan Esteban Gomez-Mesa, James L. Januzzi, Marvin Konstam, Rhonda Monroe, Elijah Ogola, Vinayagam Palaniappan, Mark C. Petrie, Fausto J. Pinto, Girish C. Rajadhyaksha, Amina Rakisheva, Carlos E. Ramos, Victor Rossel, Naoki Sato, P. Christian Schulze, Andrew Sindone, Hadi N. Skouri, Harriette G.C. Van Spall, Aistė Štaraitė, Lynne Warner Stevenson, Kadhim Sulaiman, Tzung-Dau Wang, Michael Böhm, Andrew J.S. Coats, Shelley Zieroth
    2025-06-30
    https://doi.org/10.4081/cardio.2025.70
    11908
    PDF: 7860
    Appendix: 1044
  • Adherence to lifestyle therapy in patients with chronic heart failure and comorbidity

    Elena Efremova, Alexander Shutov
    2023-12-20
    https://doi.org/10.4081/cardio.2023.8
    1219
    pdf: 253
    HTML: 24
  • Evaluating serum galectin-3 binding protein as a diagnostic and prognostic biomarker in pulmonary arterial hypertension: a comparative study

    Arif Albulushi, Lama S. Alfehaid, Mosaad Alhussein, Amr Youssef
    2024-12-30
    https://doi.org/10.4081/cardio.2024.50
    1767
    PDF: 475
    HTML: 4
  • Draft Document for Public Consultation: iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025

    Writing Task Force | iCARDIO-Alliance
    2024-12-30
    https://doi.org/10.4081/cardio.2024.59
    4873
    iCardio Guidelines: 867
    Comment form - closed: 142
  • Depression, health-related quality of life and life satisfaction in patients with heart failure

    Natasa Sedlar Kobe, Daniel Omersa, Mitja Lainscak, Jerneja Farkas
    2024-11-05
    https://doi.org/10.4081/cardio.2024.47
    2824
    PDF: 686
    HTML: 2
  • Rationale and design for the peripartum cardiomyopathy in Nigeria (PEACE) registry

    Kamilu M. Karaye, Idris Y. Mohammed, Okechukwu S. Ogah, Basil N. Okeahialam
    2023-11-28
    https://doi.org/10.4081/cardio.2023.4
    998
    pdf: 227
    HTML: 44
  • Treatment pathways in patients with heart failure with preserved ejection fraction and obesity: perspectives from cardiology specialists and patients

    Javed Butler, Sanjiv J. Shah, Melissa Magwire, Carlos Campos, Muhammad Shariq Usman, Anthony Hoovler, Anup Sabharwal, Barry A. Borlaug
    2024-06-28
    https://doi.org/10.4081/cardio.2024.38
    1918
    PDF: 518
    SUPPLEMENTARY MATERIAL: 300
    GRAPHICAL ABSTRACT: 265
    HTML: 26
  • Impella vs intra-aortic balloon pump in patients with acute myocardial infarction complicated with cardiogenic shock: an updated systematic review and meta-analysis

    Muhammad Ahmed, Serish Bano, Mutahira Asif, F.N.U. Sidra, Meva Ram, Shahida Bibi
    2025-04-16
    https://doi.org/10.4081/cardio.2025.61
    3300
    PDF: 718
    Supplementary: 378
    HTML: 0
  • Detection of early heart failure with preserved ejection fraction in metabolic syndrome patients detected as part of a national screening program in middle aged subjects

    Jelena Čelutkienė, Agnė Monika Jakštaitė, Jolita Badarienė, Svetlana Solovjova, Ieva Slivovskaja, Rokas Navickas, Edita Kazėnaitė, Egidija Rinkūnienė, Alma Čypienė, Jonas Misiūra, Ligita Ryliškytė, Aleksandras Laucevičius, Andrew J.S. Coats
    2023-12-29
    https://doi.org/10.4081/cardio.2023.3
    1564
    pdf: 235
    HTML: 5
  • Large language models to write scientific manuscripts: to be considered but not trusted

    Christian Basile, Stefan D. Anker, Gianluigi Savarese
    2025-06-30
    https://doi.org/10.4081/cardio.2025.74
    758
    PDF: 211
    HTML: 5
  • Defining iron replete status in patients with heart failure treated with intravenous iron

    Khawaja M. Talha, Javed Butler, Stephan von Haehling, Mitja Lainscak, Piotr Ponikowski, Stefan D. Anker
    2023-12-21
    https://doi.org/10.4081/cardio.2023.17
    2961
    pdf: 311
    HTML: 52
  • Frequency of low-density-lipoprotein-cholesterol measurement and risk of major adverse cardiovascular outcomes: a 5-million-person nationwide cohort study

    Denis M. Ngina, Wolfram Doehner, George Ntaios, Yvonne Nartey, Ralph K. Akyea
    2025-09-30
    https://doi.org/10.4081/cardio.2025.85
    218
    PDF: 435
    HTML: 42
  • The impact of maternal congenital heart disease on pregnancy outcomes in Malta: a retrospective study

    Maryanne Caruana, Miriam Gatt, Oscar Aquilina, Charles Savona Ventura, Victor Grech, Jane Somerville
    2023-12-29
    https://doi.org/10.4081/cardio.2023.14
    1528
    pdf: 134
    HTML: 2
  • AI-generated

    The association of iron deficiency with right ventricular dysfunction in Africans with heart failure

    Adeseye A. Akintunde, Sope T. Orugun
    2024-12-30
    https://doi.org/10.4081/cardio.2024.53
    2299
    PDF: 390
    Appendix B: 436
    Appendix A: 318
    HTML: 2
  • Is the obesity paradox present in left ventricular assist device recipients? A BMI-based analysis

    Saad Ahmed Waqas, Hibah Siddiqui, Faouzi Kallel, Shahzad Hassan
    2025-09-30
    https://doi.org/10.4081/cardio.2025.84
    175
    PDF: 225
    Supplementary: 147
    HTML: 21
  • Iron supplementation in heart failure and iron deficiency: does it help?

    Laibah Arshad Khan, Syed Sarmad Javaid, Javed Butler
    2025-09-30
    https://doi.org/10.4081/cardio.2025.82
    216
    PDF: 290
    HTML: 48
  • Exercise capacity, iron deficiency and depressive symptoms in patients with asymptomatic chronic systolic heart failure

    Sven Christopher Aland, Christoph Gertler, Hannah Leonie Bräunig, Timo Schröder, Frank Edelmann, Rolf Wachter, Christoph Herrmann-Lingen, Gerd Hasenfuß, Anja Sandek
    2024-06-28
    https://doi.org/10.4081/cardio.2024.39
    1519
    PDF: 450
    HTML: 4
  • Advancements in transcatheter tricuspid valve repair and replacement: a state-of-the-art review with echocardiographic outcomes

    Asad Gul Rao, Syed Sarmad Javaid, Ahmed Mustafa Rashid, Fawaz Alenezi
    2025-09-15
    https://doi.org/10.4081/cardio.2025.81
    330
    PDF: 342
    HTML: 122
  • The effect of sauna on cardiac and skeletal muscle function in patients with HFpEF (SAUNA-HFpEF): rationale and design

    Tarek Bekfani, Kris G. Vargas, Flor Gomez, Alexander Schmeisser, Ruediger C. Braun-Dullaeus
    2025-06-30
    https://doi.org/10.4081/cardio.2025.67
    2142
    PDF: 465
    HTML: 98
  • Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial

    Stephan von Haehling, Wolfram Doehner, Ruben Evertz, Tania Garfias-Veitl, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, Piotr Ponikowski, Michael Böhm, Tim Friede, Stefan D. Anker
    2023-12-27
    https://doi.org/10.4081/cardio.2023.15
    2534
    pdf: 552
    HTML: 30
  • Baseline echocardiographic characteristics of patients enrolled in the randomized investigation of MitraClip device in heart failure (RESHAPE HF-2) trial: comparison with COAPT and Mitra-FR

    Ralph Stephan von Bardeleben, Muhammad Shahzeb Khan, Martin Geyer, Tim Friede, Javed Butler, Monika Diek, Jutta Heinrich, Marius Placzek, Roberto Ferrari, William T. Abraham, Ottavio Alfieri, Angelo Auricchio, Antoni Bayes-Genis, John G.F. Cleland, Gerasimos Filippatos, Finn Gustafsson, Wilhelm Haverkamp, Malte Kelm, Karl-Heinz Kuck, Ulf Landmesser, Aldo P. Maggioni, Marco Metra, Vlasis Ninios, Mark C. Petrie, Tienush Rassaf, Frank Ruschitzka, Ulrich Schäfer, P. Christian Schulze, Konstantinos Spargias, Alec Vahanian, Jose Luis Zamorano, Andreas Zeiher, Mahir Karakas, Friedrich Koehler, Mitja Lainscak, Alper Öner, Nikolaos Mezilis, Efstratios K. Theofilogiannakos, Ilias Ninios, Michael Chrissoheris, Panagiota Kourkoveli, Konstantinos Papadopoulos, Grzegorz Smolka, Wojciech Wojakowski, Krzysztof Reczuch, Fausto J. Pinto, Łukasz Wiewiórka, Zbigniew Kalarus, Marianna Adamo, Evelyn Santiago-Vacas, Tobias Friedrich Ruf, Michael Gross, Joern Tongers, Gerd Hasenfuß, Wolfgang Schillinger, Piotr Ponikowski, Stefan D. Anker
    2024-06-28
    https://doi.org/10.4081/cardio.2024.40
    5336
    PDF: 727
    HTML: 28
  • The scientific targets: the myocardium, the vasculature and the body’s response to heart failure

    Rafael Vidal-Pérez, Ewa A. Jankowska
    2024-03-28
    https://doi.org/10.4081/cardio.2024.19
    2670
    PDF: 205
    HTML: 21
  • Prognostic factors and outcome in patients submitted into coronary artery bypass surgery with total arterial myocardial revascularization

    Elias Tassoulas, Dimitrios Tasoulas, Christos Papaconstantinou, Ioannis Chlorogiannis
    2024-12-30
    https://doi.org/10.4081/cardio.2024.46
    2629
    PDF: 447
    HTML: 20
  • Clinical trial design, endpoints and regulatory considerations in heart failure

    Giuseppe M.C. Rosano
    2024-03-28
    https://doi.org/10.4081/cardio.2024.18
    5659
    PDF: 457
    HTML: 69
  • Bridging the gap between study outcomes and real-world results. Algorithm-driven management in a rural cardioMEMS population

    Marc Atzenhoefer, Elizabeth Dille, Rebecca Steinke, Nicole Weigert, Keri Sabel, Kirsten Rasmussen
    2025-04-16
    https://doi.org/10.4081/cardio.2025.63
    3135
    PDF: 635
    HTML: 19
  • Clinical profiles and short-term outcomes of women with peripartum and dilated cardiomyopathies

    Babalawan Muhammad, Naser A. Ishaq, Kamilu M. Karaye
    2024-11-05
    https://doi.org/10.4081/cardio.2024.42
    2095
    PDF: 575
    HTML: 3
  • Sex-based differences in characteristics, management, and outcomes in heart failure with reduced ejection fraction

    Christian Basile, Stefan D. Anker, Gianluigi Savarese
    2025-06-30
    https://doi.org/10.4081/cardio.2025.73
    763
    PDF: 212
    Supplementary: 142
    Appendix: 111
    HTML: 32
  • Elevated left ventricular end diastolic pressure, chronic pulmonary oedema and valve disease

    Prithwish Banerjee
    2024-04-08
    https://doi.org/10.4081/cardio.2024.23
    1963
    PDF: 166
    HTML: 705
  • Sex differences in clinical characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction

    Christian Basile, Stefan D. Anker, Gianluigi Savarese
    2025-07-16
    https://doi.org/10.4081/cardio.2025.76
    775
    PDF: 190
    Supplementary: 151
    Appendix: 105
    HTML: 36
  • Tricuspid valve fungal endocarditis in a patient with breast cancer and an implantable chemotherapy venous access port

    Petros Fountoulakis, Aikaterini Siama, Aimilianos Kalogeris, Marianthi Iliopoulou, Athanasios Tsoukas, Athanasios Manolis
    2023-12-18
    https://doi.org/10.4081/cardio.2023.7
    693
    pdf: 143
    HTML: 4
  • Demographic and regional trends of heart failure and cachexia-related mortality among older adults in the United States, from 1999 to 2020

    Ishaque Hameed, Muhammad Nashit, Zahra Quettawala Mufaddal, Syed Sarmad Javaid, Muhammad Hanif
    2025-09-19
    https://doi.org/10.4081/cardio.2025.83
    196
    PDF: 198
    HTML: 32
  • Evolving targets for heart failure: the journey so far

    Giuseppe M.C. Rosano, Jerneja Farkas
    2023-11-28
    https://doi.org/10.4081/cardio.2023.6
    2025
    pdf: 322
    HTML: 4
  • Welcome to Global Cardiology

    Andrew J.S. Coats
    2023-12-20
    https://doi.org/10.4081/cardio.2023.1
    2361
    pdf: 152
    HTML: 4
  • Prevalence of left ventricular dysfunction and relationship with serum selenium in apparently healthy pregnant women: results from the PEACE registry

    Kamilu M. Karaye, Idris Y. Mohammed, Hadiza Sa’idu, Naser A. Ishaq, Suleiman A. Balarabe, Jamilu Tukur, Tewogbade A. Adedeji, Olufemiwa N. Makinde, Rasaaq A. Adebayo
    2024-06-28
    https://doi.org/10.4081/cardio.2024.36
    1598
    PDF: 389
    HTML: 2
  • Safety and efficacy of left atrial appendage closure in cancer versus non-cancer patients: a systematic review and meta-analysis

    Muhammad Ahmed, Fatima Muskan, Mohsin Zaheer, Manesh Kumar, Sawera Gul, Abdul Hadi Ansari, Muhammad Sameer Jamal, Muhammad Sohaib Asghar, M. Chadi Alraies, Shiny Teja Kolli, Praveen Kumar Komminni, Priya Hotwani, Vishal Reddy Bejugam
    2025-06-30
    https://doi.org/10.4081/cardio.2025.72
    1111
    PDF: 259
    Supplementary: 157
    HTML: 89
  • The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis

    Muhammad Shariq Usman, Arsalan Hamid, Shurjeel Uddin Qazi, Mikhail N. Kosiborod, Deepak L. Bhatt, Muhammad Shahzeb Khan, Muthiah Vaduganathan, Javed Butler
    2024-06-28
    https://doi.org/10.4081/cardio.2024.35
    2475
    PDF: 656
    Conflict of interest: 320
    SUPPLEMENTARY MATERIAL: 256
    HTML: 61
  • Optimized heart failure therapy in patients with very advanced cancer in palliative care: dosing strategies from the EMPATICC trial

    Markus S. Anker, Sven Bercker, Ulrich Laufs, Michael Böhm, Bela Merkely, Monika Diek, Tim Heise, Martin Hellmich, Marius Placzek, Tim Friede, Stefan D. Anker, Lorenz Lehmann, Ulf Landmesser, Dominik P. Modest, Muhammad Shahzeb Khan, Amir A. Mahabadi, Matthias Totzeck, Mitra Tewes, Muhammad Sameer Arshad, Raluca Mincu, Javed Butler, Ulrich Keller, Johann Ahn, Lars Bullinger, Tienush Rassaf
    2025-08-20
    https://doi.org/10.4081/cardio.2025.78
    365
    PDF: 341
    Appendix: 208
    HTML: 52
  • AI-generated

    Unveiling the genetic aetiology of non-genetic dilated cardiomyopathy

    Emanuele Monda, Giuseppe Limongelli
    2024-12-30
    https://doi.org/10.4081/cardio.2024.54
    2426
    PDF: 419
    HTML: 6
  • SGLT2 inhibitors and risk reduction for mortality in high-risk patients: a meta-analysis of randomized controlled trials

    Tariq Jamal Siddiqi, Javed Butler, Andrew J.S. Coats, Subodh Verma, Tim Friede, Gerasimos Filippatos, Stefan D. Anker
    2023-11-23
    https://doi.org/10.4081/cardio.2023.2
    1108
    pdf: 243
    Supplementary Material: 39
    HTML: 120
  • Modulation of cardiac metabolism in heart failure

    Giuseppe M.C. Rosano, Andrew J.S. Coats
    2024-11-05
    https://doi.org/10.4081/cardio.2024.30
    2341
    PDF: 1146
    HTML: 26
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iCARDIO

May 1 marked the release of the #iCARDIO Guidelines on Heart Failure, now live in Global Cardiology. This global-first effort brings flexible, practical guidance to frontline providers managing #heartfailure in any setting. www.globalcardiology.info/site/article... #GlobalHealth #cardiosky

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— iCardio (@icardio.bsky.social) May 13, 2025 at 8:26

Keywords

Vol. 3 No. 4 (2025)
Effect of metformin and empagliflozin on myocardial function in insulin-resistant patients with heart failure: rationale and design of the...

Impaired energy metabolism contributed to clinical severity, disease progression and to outcome in heart failure (HF). Insulin sensitivity (IS) is a key metabolic factor in the control of energy substrate utilisation and energy efficiency in cardiac and skeletal muscle. Impaired IS, or insulin resistance, is a common finding in HF and has been shown to predict morbidity and mortality in patients with heart failure with reduced and mildly reduced ejection fraction (HFrEF, HFmrEF). Despite its pathophysiologic relevance, IS has not been...

Wolfram Doehner et al.
31 December 2025
Vol. 3 No. 4 (2025)
Aldosterone synthase inhibitors in cardio-renal diseases: a state-of-the-art review

Aldosterone plays a pivotal role in the progression of cardio-renal diseases by driving myocardial fibrosis, vascular dysfunction, and renal injury through both genomic and non-genomic mechanisms. While mineralocorticoid receptor antagonists have long served as the cornerstone of pharmacologic intervention, their use is limited by adverse effects such as hyperkalemia, gynecomastia, and incomplete suppression of aldosterone-mediated pathology. Aldosterone synthase inhibitors, a novel class of therapeutics, offer a promising alternative by...

Muhammad Hamza Dawood et al.
31 December 2025
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