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Global Cardiology

eISSN 2975-2728

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Editor-in-Chief: Andrew J.S. Coats, Australia

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  • Bridging the gap between study outcomes and real-world results. Algorithm-driven management in a rural cardioMEMS population

    Marc Atzenhoefer, Elizabeth Dille, Rebecca Steinke, Nicole Weigert, Keri Sabel, Kirsten Rasmussen
    2025-04-16
    https://doi.org/10.4081/cardio.2025.63
    3151
    PDF: 640
    HTML: 19
  • The scientific targets: the myocardium, the vasculature and the body’s response to heart failure

    Rafael Vidal-Pérez, Ewa A. Jankowska
    2024-03-28
    https://doi.org/10.4081/cardio.2024.19
    2691
    PDF: 208
    HTML: 21
  • Modulation of cardiac metabolism in heart failure

    Giuseppe M.C. Rosano, Andrew J.S. Coats
    2024-11-05
    https://doi.org/10.4081/cardio.2024.30
    2358
    PDF: 1151
    HTML: 27
  • Treatment pathways in patients with heart failure with preserved ejection fraction and obesity: perspectives from cardiology specialists and patients

    Javed Butler, Sanjiv J. Shah, Melissa Magwire, Carlos Campos, Muhammad Shariq Usman, Anthony Hoovler, Anup Sabharwal, Barry A. Borlaug
    2024-06-28
    https://doi.org/10.4081/cardio.2024.38
    1954
    PDF: 520
    SUPPLEMENTARY MATERIAL: 301
    GRAPHICAL ABSTRACT: 265
    HTML: 27
  • Evolving targets for heart failure: the journey so far

    Giuseppe M.C. Rosano, Jerneja Farkas
    2023-11-28
    https://doi.org/10.4081/cardio.2023.6
    2041
    pdf: 329
    HTML: 4
  • Sex-based differences in characteristics, management, and outcomes in heart failure with reduced ejection fraction

    Christian Basile, Stefan D. Anker, Gianluigi Savarese
    2025-06-30
    https://doi.org/10.4081/cardio.2025.73
    779
    PDF: 219
    Supplementary: 142
    Appendix: 111
    HTML: 38
  • The effect of sauna on cardiac and skeletal muscle function in patients with HFpEF (SAUNA-HFpEF): rationale and design

    Tarek Bekfani, Kris G. Vargas, Flor Gomez, Alexander Schmeisser, Ruediger C. Braun-Dullaeus
    2025-06-30
    https://doi.org/10.4081/cardio.2025.67
    2159
    PDF: 471
    HTML: 106
  • Clinical trial design, endpoints and regulatory considerations in heart failure

    Giuseppe M.C. Rosano
    2024-03-28
    https://doi.org/10.4081/cardio.2024.18
    5671
    PDF: 458
    HTML: 69
  • Sex differences in clinical characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction

    Christian Basile, Stefan D. Anker, Gianluigi Savarese
    2025-07-16
    https://doi.org/10.4081/cardio.2025.76
    786
    PDF: 194
    Supplementary: 151
    Appendix: 105
    HTML: 37
  • Baseline echocardiographic characteristics of patients enrolled in the randomized investigation of MitraClip device in heart failure (RESHAPE HF-2) trial: comparison with COAPT and Mitra-FR

    Ralph Stephan von Bardeleben, Muhammad Shahzeb Khan, Martin Geyer, Tim Friede, Javed Butler, Monika Diek, Jutta Heinrich, Marius Placzek, Roberto Ferrari, William T. Abraham, Ottavio Alfieri, Angelo Auricchio, Antoni Bayes-Genis, John G.F. Cleland, Gerasimos Filippatos, Finn Gustafsson, Wilhelm Haverkamp, Malte Kelm, Karl-Heinz Kuck, Ulf Landmesser, Aldo P. Maggioni, Marco Metra, Vlasis Ninios, Mark C. Petrie, Tienush Rassaf, Frank Ruschitzka, Ulrich Schäfer, P. Christian Schulze, Konstantinos Spargias, Alec Vahanian, Jose Luis Zamorano, Andreas Zeiher, Mahir Karakas, Friedrich Koehler, Mitja Lainscak, Alper Öner, Nikolaos Mezilis, Efstratios K. Theofilogiannakos, Ilias Ninios, Michael Chrissoheris, Panagiota Kourkoveli, Konstantinos Papadopoulos, Grzegorz Smolka, Wojciech Wojakowski, Krzysztof Reczuch, Fausto J. Pinto, Łukasz Wiewiórka, Zbigniew Kalarus, Marianna Adamo, Evelyn Santiago-Vacas, Tobias Friedrich Ruf, Michael Gross, Joern Tongers, Gerd Hasenfuß, Wolfgang Schillinger, Piotr Ponikowski, Stefan D. Anker
    2024-06-28
    https://doi.org/10.4081/cardio.2024.40
    5356
    PDF: 733
    HTML: 29
  • Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial

    Stephan von Haehling, Wolfram Doehner, Ruben Evertz, Tania Garfias-Veitl, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, Piotr Ponikowski, Michael Böhm, Tim Friede, Stefan D. Anker
    2023-12-27
    https://doi.org/10.4081/cardio.2023.15
    2549
    pdf: 567
    HTML: 30
  • Cardiac wasting in patients with advanced cancer: state of the art review

    Laibah Arshad Khan, Muhammad Shahzeb Khan, Rania Usman Latif, Markus S. Anker
    2025-04-16
    https://doi.org/10.4081/cardio.2025.65
    2426
    PDF: 499
    HTML: 41
  • Iron supplementation in heart failure and iron deficiency: does it help?

    Laibah Arshad Khan, Syed Sarmad Javaid, Javed Butler
    2025-09-30
    https://doi.org/10.4081/cardio.2025.82
    252
    PDF: 298
    HTML: 50
  • Adherence to lifestyle therapy in patients with chronic heart failure and comorbidity

    Elena Efremova, Alexander Shutov
    2023-12-20
    https://doi.org/10.4081/cardio.2023.8
    1226
    pdf: 263
    HTML: 25
  • Depression, health-related quality of life and life satisfaction in patients with heart failure

    Natasa Sedlar Kobe, Daniel Omersa, Mitja Lainscak, Jerneja Farkas
    2024-11-05
    https://doi.org/10.4081/cardio.2024.47
    2836
    PDF: 690
    HTML: 2
  • AI-generated

    The association of iron deficiency with right ventricular dysfunction in Africans with heart failure

    Adeseye A. Akintunde, Sope T. Orugun
    2024-12-30
    https://doi.org/10.4081/cardio.2024.53
    2323
    PDF: 396
    Appendix B: 436
    Appendix A: 321
    HTML: 2
  • Defining iron replete status in patients with heart failure treated with intravenous iron

    Khawaja M. Talha, Javed Butler, Stephan von Haehling, Mitja Lainscak, Piotr Ponikowski, Stefan D. Anker
    2023-12-21
    https://doi.org/10.4081/cardio.2023.17
    2977
    pdf: 319
    HTML: 54
  • Exercise capacity, iron deficiency and depressive symptoms in patients with asymptomatic chronic systolic heart failure

    Sven Christopher Aland, Christoph Gertler, Hannah Leonie Bräunig, Timo Schröder, Frank Edelmann, Rolf Wachter, Christoph Herrmann-Lingen, Gerd Hasenfuß, Anja Sandek
    2024-06-28
    https://doi.org/10.4081/cardio.2024.39
    1528
    PDF: 455
    HTML: 4
  • Detection of early heart failure with preserved ejection fraction in metabolic syndrome patients detected as part of a national screening program in middle aged subjects

    Jelena Čelutkienė, Agnė Monika Jakštaitė, Jolita Badarienė, Svetlana Solovjova, Ieva Slivovskaja, Rokas Navickas, Edita Kazėnaitė, Egidija Rinkūnienė, Alma Čypienė, Jonas Misiūra, Ligita Ryliškytė, Aleksandras Laucevičius, Andrew J.S. Coats
    2023-12-29
    https://doi.org/10.4081/cardio.2023.3
    1572
    pdf: 239
    HTML: 5
  • Optimized heart failure therapy in patients with very advanced cancer in palliative care: dosing strategies from the EMPATICC trial

    Markus S. Anker, Sven Bercker, Ulrich Laufs, Michael Böhm, Bela Merkely, Monika Diek, Tim Heise, Martin Hellmich, Marius Placzek, Tim Friede, Stefan D. Anker, Lorenz Lehmann, Ulf Landmesser, Dominik P. Modest, Muhammad Shahzeb Khan, Amir A. Mahabadi, Matthias Totzeck, Mitra Tewes, Muhammad Sameer Arshad, Raluca Mincu, Javed Butler, Ulrich Keller, Johann Ahn, Lars Bullinger, Tienush Rassaf
    2025-08-20
    https://doi.org/10.4081/cardio.2025.78
    382
    PDF: 349
    Appendix: 210
    HTML: 52
  • The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis

    Muhammad Shariq Usman, Arsalan Hamid, Shurjeel Uddin Qazi, Mikhail N. Kosiborod, Deepak L. Bhatt, Muhammad Shahzeb Khan, Muthiah Vaduganathan, Javed Butler
    2024-06-28
    https://doi.org/10.4081/cardio.2024.35
    2502
    PDF: 658
    Conflict of interest: 320
    SUPPLEMENTARY MATERIAL: 256
    HTML: 63
  • Advanced cancer as a heart failure like syndrome due to cardiac wasting cardiomyopathy: facts and numbers

    Muhammad Shahzeb Khan, Javed Butler, Laibah Arshad Khan, Markus S. Anker
    2024-12-30
    https://doi.org/10.4081/cardio.2024.58
    3109
    PDF: 541
    HTML: 64
  • Demographic and regional trends of heart failure and cachexia-related mortality among older adults in the United States, from 1999 to 2020

    Ishaque Hameed, Muhammad Nashit, Zahra Quettawala Mufaddal, Syed Sarmad Javaid, Muhammad Hanif
    2025-09-19
    https://doi.org/10.4081/cardio.2025.83
    210
    PDF: 202
    HTML: 32
  • iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on prevention and treatment of cardiometabolic disease

    Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J.S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuanlin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss Quintana, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed , Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano Ruiz, Nandini Chatterjee, Vijay Chopra, Marc-André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M.C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Yuhui Zhang, Martha Gulati, Naveed Sattar, José Luis Zamorano
    2025-09-30
    https://doi.org/10.4081/cardio.2025.86
    1147
    PDF: 36
    Supplementary: 318
    Appendix: 265
  • The impact of maternal congenital heart disease on pregnancy outcomes in Malta: a retrospective study

    Maryanne Caruana, Miriam Gatt, Oscar Aquilina, Charles Savona Ventura, Victor Grech, Jane Somerville
    2023-12-29
    https://doi.org/10.4081/cardio.2023.14
    1541
    pdf: 136
    HTML: 2
  • Lipoprotein(a): what clinicians need to know

    Laibah Arshad Khan, Muhammad Hanif, Ahmed Mustafa Rashid
    2025-09-01
    https://doi.org/10.4081/cardio.2025.80
    343
    PDF: 702
    HTML: 23
  • Using multiple primary endpoints in clinical trials with a focus on heart failure

    Stefan D. Anker, Javed Butler, Khawaja M. Talha, Tim Friede
    2024-06-28
    https://doi.org/10.4081/cardio.2024.33
    5551
    PDF: 733
    HTML: 201
  • The impact of frailty on in-hospital outcomes in patients with HFrEF

    Saad Ahmed Waqas, Taimor Mohammed Khan, Ahmed Kamal Siddiqi, Shahzad Hassan, Stefan D. Anker
    2025-12-17
    https://doi.org/10.4081/cardio.2025.88
    150
    PDF: 53
    Supplementary: 11
    HTML: 1
  • Advancements in transcatheter tricuspid valve repair and replacement: a state-of-the-art review with echocardiographic outcomes

    Asad Gul Rao, Syed Sarmad Javaid, Ahmed Mustafa Rashid, Fawaz Alenezi
    2025-09-15
    https://doi.org/10.4081/cardio.2025.81
    365
    PDF: 355
    HTML: 134
  • Is the obesity paradox present in left ventricular assist device recipients? A BMI-based analysis

    Saad Ahmed Waqas, Hibah Siddiqui, Faouzi Kallel, Shahzad Hassan
    2025-09-30
    https://doi.org/10.4081/cardio.2025.84
    189
    PDF: 236
    Supplementary: 150
    HTML: 21
  • Epidemiology of peripartum cardiomyopathy in Africa

    Kamilu M. Karaye, Abdulrazaq G. Habib, Karen Sliwa
    2024-06-28
    https://doi.org/10.4081/cardio.2024.31
    2285
    PDF: 506
    HTML: 99
  • Quality of life in Maltese adults with congenital heart disease: a second look An APPROACH-IS substudy

    Maryanne Caruana, Philip Moons, Adrienne H. Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Maayke Sluman, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Alexandra Soufi, Edward Callus, Victor Grech, Silke Apers
    2024-03-28
    https://doi.org/10.4081/cardio.2024.26
    1652
    PDF: 158
    HTML: 9
  • Intervention options: depression and cardiovascular disease during COVID-19

    Eirini Flouda, Athena Stefanatou, Tinia Apergi
    2023-11-28
    https://doi.org/10.4081/cardio.2023.5
    1807
    pdf: 250
    HTML: 21
  • Preliminary study on the immunohistochemical expression of galectin-3 in hypertrophic hearts

    Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo
    2024-06-28
    https://doi.org/10.4081/cardio.2024.37
    1326
    PDF: 326
    HTML: 12
  • Importance of patient-reported outcomes in cardiovascular illnesses

    Wardah Rasool, Ahmed Kamal Siddiqi, Laibah Arshad Khan
    2025-06-30
    https://doi.org/10.4081/cardio.2025.69
    1985
    PDF: 425
    HTML: 108
  • iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025

    Vijay Chopra, Muhammad Shahzeb Khan, Magdy Abdelhamid, William T. Abraham, Offer Amir, Stefan D. Anker, John J. Atherton, Fernando Bacal, Ralph Stephan von Bardeleben, Dulce Brito, Lucrecia Maria Burgos, Javed Butler, Maria Rosa Costanzo, Albertino Damasceno, Justin A. Ezekowitz, Ishaque Hameed, Sivadasanpillai Harikrishnan, Tiny Jaarsma, Anuradha Lala, Ileana L. Piña, Clara Saldarriaga, David Sim, John R. Teerlink, Nqoba Tsabedze, Hiroyuki Tsutsui, Jing Yu, Yuhui Zhang, Mohammad Zubaid, Nikhil Balankhe, Juan Esteban Gomez-Mesa, James L. Januzzi, Marvin Konstam, Rhonda Monroe, Elijah Ogola, Vinayagam Palaniappan, Mark C. Petrie, Fausto J. Pinto, Girish C. Rajadhyaksha, Amina Rakisheva, Carlos E. Ramos, Victor Rossel, Naoki Sato, P. Christian Schulze, Andrew Sindone, Hadi N. Skouri, Harriette G.C. Van Spall, Aistė Štaraitė, Lynne Warner Stevenson, Kadhim Sulaiman, Tzung-Dau Wang, Michael Böhm, Andrew J.S. Coats, Shelley Zieroth
    2025-06-30
    https://doi.org/10.4081/cardio.2025.70
    12000
    PDF: 7906
    Appendix: 1049
  • The muscle hypothesis of shortness of breath in patients with cachexia

    Stefan D. Anker, Muhammad Shahzeb Khan, Laibah Arshad Khan, Giuseppe M.C. Rosano, Maurizio Volterrani, Mitja Lainscak, Piotr Ponikowski, Andrew J.S. Coats
    2024-12-30
    https://doi.org/10.4081/cardio.2024.57
    2514
    PDF: 694
    HTML: 12
  • Biological plausibility and implications of obesity associated valvular heart diseases

    Francesco Fioretti, Brian R. Lindman, Javed Butler
    2024-11-05
    https://doi.org/10.4081/cardio.2024.49
    2541
    PDF: 665
    HTML: 3
  • SGLT2 inhibitors and risk reduction for mortality in high-risk patients: a meta-analysis of randomized controlled trials

    Tariq Jamal Siddiqi, Javed Butler, Andrew J.S. Coats, Subodh Verma, Tim Friede, Gerasimos Filippatos, Stefan D. Anker
    2023-11-23
    https://doi.org/10.4081/cardio.2023.2
    1125
    pdf: 246
    Supplementary Material: 40
    HTML: 123
  • AI generated

    Relaxin-2 for heart failure with preserved ejection fraction: a comment on the termination of a phase-II trial investigating the relaxin-2 analogue, LY3540378

    Thomas Bernd Dschietzig, Guy Salama
    2024-12-30
    https://doi.org/10.4081/cardio.2024.56
    3991
    PDF: 915
    HTML: 81
  • To clip or not to clip moderate-to-severe functional mitral regurgitation in patients with heart failure?

    Muhammad Shahzeb Khan, Javed Butler, Tim Friede, Piotr Ponikowski, Stefan D. Anker
    2024-11-05
    https://doi.org/10.4081/cardio.2024.44
    3013
    PDF: 774
    HTML: 18
  • Clinical profiles and short-term outcomes of women with peripartum and dilated cardiomyopathies

    Babalawan Muhammad, Naser A. Ishaq, Kamilu M. Karaye
    2024-11-05
    https://doi.org/10.4081/cardio.2024.42
    2099
    PDF: 576
    HTML: 3
  • The impact of diurnal fasting during Ramadan on patients with established cardiac disease: a systematic review

    Marwan M. Refaat, Nadim El Jamal, Hebah M. El-Rayess, Anthony Gebran, Amar M. Salam
    2024-06-28
    https://doi.org/10.4081/cardio.2024.32
    2375
    PDF: 837
    HTML: 15
  • COVID-19 myocarditis

    Reinaldo B. Bestetti, Rosemary Furlan-Daniel, Luciano P. Pereira
    2024-03-28
    https://doi.org/10.4081/cardio.2024.21
    2704
    PDF: 233
    HTML: 14
  • Rationale and design for the peripartum cardiomyopathy in Nigeria (PEACE) registry

    Kamilu M. Karaye, Idris Y. Mohammed, Okechukwu S. Ogah, Basil N. Okeahialam
    2023-11-28
    https://doi.org/10.4081/cardio.2023.4
    1007
    pdf: 232
    HTML: 47
  • The Global Implementation Guidelines Initiative: how to optimize cardio-renal-metabolic care worldwide

    Fausto J. Pinto, Stefan D. Anker, William T. Abraham, John J. Atherton, Javed Butler, Vijay Chopra, Andrew J.S. Coats, Yann Colardelle, Maria Rosa Costanzo, Veronica Dean, Gerasimos Filippatos, Martha Gulati, Julio Rosenstock, John Teerlink, Subodh Verma, Jose Luis Zamorano, Yuhui Zhang, Shelley Zieroth
    2025-04-16
    https://doi.org/10.4081/cardio.2025.68
    3378
    PDF: 537
    Appendix: 393
    HTML: 27
  • Applicability of obesity clinical practice guidelines in low- and middle-income countries

    Shelley Zieroth, Fausto Pinto, Stefan D. Anker, William T. Abraham, John J. Atherton, Javed Butler, Vijay Chopra, Andrew J.S. Coats, Martha Gulati, Tammy L. Kindel, José Luis Zamorano, Yuhui Zhang, Linong Ji, Yann Colardelle, Richard B. Weiskopf
    2025-06-30
    https://doi.org/10.4081/cardio.2025.77
    1153
    PDF: 586
    Appendix: 237
    HTML: 21
  • Evaluating serum galectin-3 binding protein as a diagnostic and prognostic biomarker in pulmonary arterial hypertension: a comparative study

    Arif Albulushi, Lama S. Alfehaid, Mosaad Alhussein, Amr Youssef
    2024-12-30
    https://doi.org/10.4081/cardio.2024.50
    1777
    PDF: 493
    HTML: 5
  • Global Cardiology issue highlights

    Andrew J.S. Coats
    2024-06-28
    https://doi.org/10.4081/cardio.2024.41
    3472
    PDF: 400
    HTML: 0
  • Elevated left ventricular end diastolic pressure, chronic pulmonary oedema and valve disease

    Prithwish Banerjee
    2024-04-08
    https://doi.org/10.4081/cardio.2024.23
    1980
    PDF: 168
    HTML: 718
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iCARDIO

May 1 marked the release of the #iCARDIO Guidelines on Heart Failure, now live in Global Cardiology. This global-first effort brings flexible, practical guidance to frontline providers managing #heartfailure in any setting. www.globalcardiology.info/site/article... #GlobalHealth #cardiosky

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— iCardio (@icardio.bsky.social) May 13, 2025 at 8:26

Keywords

Vol. 3 No. 4 (2025)
Effect of metformin and empagliflozin on myocardial function in insulin-resistant patients with heart failure: rationale and design of the...

Impaired energy metabolism contributed to clinical severity, disease progression and to outcome in heart failure (HF). Insulin sensitivity (IS) is a key metabolic factor in the control of energy substrate utilisation and energy efficiency in cardiac and skeletal muscle. Impaired IS, or insulin resistance, is a common finding in HF and has been shown to predict morbidity and mortality in patients with heart failure with reduced and mildly reduced ejection fraction (HFrEF, HFmrEF). Despite its pathophysiologic relevance, IS has not been...

Wolfram Doehner et al.
31 December 2025
Vol. 3 No. 4 (2025)
Aldosterone synthase inhibitors in cardio-renal diseases: a state-of-the-art review

Aldosterone plays a pivotal role in the progression of cardio-renal diseases by driving myocardial fibrosis, vascular dysfunction, and renal injury through both genomic and non-genomic mechanisms. While mineralocorticoid receptor antagonists have long served as the cornerstone of pharmacologic intervention, their use is limited by adverse effects such as hyperkalemia, gynecomastia, and incomplete suppression of aldosterone-mediated pathology. Aldosterone synthase inhibitors, a novel class of therapeutics, offer a promising alternative by...

Muhammad Hamza Dawood et al.
31 December 2025
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