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• Bridging the gap between study outcomes and real-world results. Algorithm-driven management in a rural cardioMEMS population

  Marc Atzenhoefer, Elizabeth Dille, Rebecca Steinke, Nicole Weigert, Keri Sabel, Kirsten Rasmussen

  2025-04-16

  https://doi.org/10.4081/cardio.2025.63

  3875

  PDF: 866

  HTML: 63

• The scientific targets: the myocardium, the vasculature and the body’s response to heart failure

  Rafael Vidal-Pérez, Ewa A. Jankowska

  2024-03-28

  https://doi.org/10.4081/cardio.2024.19

  2938

  PDF: 331

  HTML: 25

• Modulation of cardiac metabolism in heart failure

  Giuseppe M.C. Rosano, Andrew J.S. Coats

  2024-11-05

  https://doi.org/10.4081/cardio.2024.30

  2596

  PDF: 1287

  HTML: 86

• Treatment pathways in patients with heart failure with preserved ejection fraction and obesity: perspectives from cardiology specialists and patients

  Javed Butler, Sanjiv J. Shah, Melissa Magwire, Carlos Campos, Muhammad Shariq Usman, Anthony Hoovler, Anup Sabharwal, Barry A. Borlaug

  2024-06-28

  https://doi.org/10.4081/cardio.2024.38

  2464

  PDF: 961

  SUPPLEMENTARY MATERIAL: 357

  GRAPHICAL ABSTRACT: 309

  HTML: 207

• Evolving targets for heart failure: the journey so far

  Giuseppe M.C. Rosano, Jerneja Farkas

  2023-11-28

  https://doi.org/10.4081/cardio.2023.6

  2392

  pdf: 472

  HTML: 4

• Sex-based differences in characteristics, management, and outcomes in heart failure with reduced ejection fraction

  Christian Basile, Stefan D. Anker, Gianluigi Savarese

  2025-06-30

  https://doi.org/10.4081/cardio.2025.73

  1087

  PDF: 377

  Supplementary: 216

  Appendix: 156

  HTML: 136
• 

  The effect of sauna on cardiac and skeletal muscle function in patients with HFpEF (SAUNA-HFpEF): rationale and design

  Tarek Bekfani, Kris G. Vargas, Flor Gomez, Alexander Schmeisser, Ruediger C. Braun-Dullaeus

  2025-06-30

  https://doi.org/10.4081/cardio.2025.67

  3106

  PDF: 619

  HTML: 152

• Clinical trial design, endpoints and regulatory considerations in heart failure

  Giuseppe M.C. Rosano

  2024-03-28

  https://doi.org/10.4081/cardio.2024.18

  5991

  PDF: 577

  HTML: 69

• Effect of metformin and empagliflozin on myocardial function in insulin-resistant patients with heart failure: rationale and design of the METRIS-HF-DZHK18 Trial

  Wolfram Doehner, Tim Friede, Frank Edelmann, Ulf Landmesser, Sebastian Winkler, Burkert Pieske, Fabian Knebel, Sebastian Kelle, Diethelm Tschöpe, Antje Meyer, Nadja Jauert, Marius Placzek, Jeanette Schulz-Menger, Stephan von Haehling, Stefan D. Anker

  2025-12-31

  https://doi.org/10.4081/cardio.2025.89

  457

  PDF: 174

  Appendix: 57

  HTML: 14

• Sex differences in clinical characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction

  Christian Basile, Stefan D. Anker, Gianluigi Savarese

  2025-07-16

  https://doi.org/10.4081/cardio.2025.76

  999

  PDF: 302

  Supplementary: 206

  Appendix: 205

  HTML: 66

• Baseline echocardiographic characteristics of patients enrolled in the randomized investigation of MitraClip device in heart failure (RESHAPE HF-2) trial: comparison with COAPT and Mitra-FR

  Ralph Stephan von Bardeleben, Muhammad Shahzeb Khan, Martin Geyer, Tim Friede, Javed Butler, Monika Diek, Jutta Heinrich, Marius Placzek, Roberto Ferrari, William T. Abraham, Ottavio Alfieri, Angelo Auricchio, Antoni Bayes-Genis, John G.F. Cleland, Gerasimos Filippatos, Finn Gustafsson, Wilhelm Haverkamp, Malte Kelm, Karl-Heinz Kuck, Ulf Landmesser, Aldo P. Maggioni, Marco Metra, Vlasis Ninios, Mark C. Petrie, Tienush Rassaf, Frank Ruschitzka, Ulrich Schäfer, P. Christian Schulze, Konstantinos Spargias, Alec Vahanian, Jose Luis Zamorano, Andreas Zeiher, Mahir Karakas, Friedrich Koehler, Mitja Lainscak, Alper Öner, Nikolaos Mezilis, Efstratios K. Theofilogiannakos, Ilias Ninios, Michael Chrissoheris, Panagiota Kourkoveli, Konstantinos Papadopoulos, Grzegorz Smolka, Wojciech Wojakowski, Krzysztof Reczuch, Fausto J. Pinto, Łukasz Wiewiórka, Zbigniew Kalarus, Marianna Adamo, Evelyn Santiago-Vacas, Tobias Friedrich Ruf, Michael Gross, Joern Tongers, Gerd Hasenfuß, Wolfgang Schillinger, Piotr Ponikowski, Stefan D. Anker

  2024-06-28

  https://doi.org/10.4081/cardio.2024.40

  5884

  PDF: 922

  HTML: 52

• Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial

  Stephan von Haehling, Wolfram Doehner, Ruben Evertz, Tania Garfias-Veitl, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, Piotr Ponikowski, Michael Böhm, Tim Friede, Stefan D. Anker

  2023-12-27

  https://doi.org/10.4081/cardio.2023.15

  2940

  pdf: 835

  HTML: 56

• Cardiac wasting in patients with advanced cancer: state of the art review

  Laibah Arshad Khan, Muhammad Shahzeb Khan, Rania Usman Latif, Markus S. Anker

  2025-04-16

  https://doi.org/10.4081/cardio.2025.65

  2963

  PDF: 752

  HTML: 76

• Iron supplementation in heart failure and iron deficiency: does it help?

  Laibah Arshad Khan, Syed Sarmad Javaid, Javed Butler

  2025-09-30

  https://doi.org/10.4081/cardio.2025.82

  954

  PDF: 536

  HTML: 86

• Adherence to lifestyle therapy in patients with chronic heart failure and comorbidity

  Elena Efremova, Alexander Shutov

  2023-12-20

  https://doi.org/10.4081/cardio.2023.8

  1451

  pdf: 433

  HTML: 46

• Depression, health-related quality of life and life satisfaction in patients with heart failure

  Natasa Sedlar Kobe, Daniel Omersa, Mitja Lainscak, Jerneja Farkas

  2024-11-05

  https://doi.org/10.4081/cardio.2024.47

  3233

  PDF: 846

  HTML: 12

• The association of iron deficiency with right ventricular dysfunction in Africans with heart failure

  Adeseye A. Akintunde, Sope T. Orugun

  2024-12-30

  https://doi.org/10.4081/cardio.2024.53

  2737

  PDF: 461

  Appendix B: 510

  Appendix A: 361

  HTML: 12

• Defining iron replete status in patients with heart failure treated with intravenous iron

  Khawaja M. Talha, Javed Butler, Stephan von Haehling, Mitja Lainscak, Piotr Ponikowski, Stefan D. Anker

  2023-12-21

  https://doi.org/10.4081/cardio.2023.17

  3366

  pdf: 509

  HTML: 78

• Exercise capacity, iron deficiency and depressive symptoms in patients with asymptomatic chronic systolic heart failure

  Sven Christopher Aland, Christoph Gertler, Hannah Leonie Bräunig, Timo Schröder, Frank Edelmann, Rolf Wachter, Christoph Herrmann-Lingen, Gerd Hasenfuß, Anja Sandek

  2024-06-28

  https://doi.org/10.4081/cardio.2024.39

  1882

  PDF: 617

  HTML: 20

• Detection of early heart failure with preserved ejection fraction in metabolic syndrome patients detected as part of a national screening program in middle aged subjects

  Jelena Čelutkienė, Agnė Monika Jakštaitė, Jolita Badarienė, Svetlana Solovjova, Ieva Slivovskaja, Rokas Navickas, Edita Kazėnaitė, Egidija Rinkūnienė, Alma Čypienė, Jonas Misiūra, Ligita Ryliškytė, Aleksandras Laucevičius, Andrew J.S. Coats

  2023-12-29

  https://doi.org/10.4081/cardio.2023.3

  1809

  pdf: 376

  HTML: 14

• Optimized heart failure therapy in patients with very advanced cancer in palliative care: dosing strategies from the EMPATICC trial

  Markus S. Anker, Sven Bercker, Ulrich Laufs, Michael Böhm, Bela Merkely, Monika Diek, Tim Heise, Martin Hellmich, Marius Placzek, Tim Friede, Stefan D. Anker, Lorenz Lehmann, Ulf Landmesser, Dominik P. Modest, Muhammad Shahzeb Khan, Amir A. Mahabadi, Matthias Totzeck, Mitra Tewes, Muhammad Sameer Arshad, Raluca Mincu, Javed Butler, Ulrich Keller, Johann Ahn, Lars Bullinger, Tienush Rassaf

  2025-08-20

  https://doi.org/10.4081/cardio.2025.78

  729

  PDF: 520

  Appendix: 264

  HTML: 73

• Mineralocorticoid receptor antagonists in heart failure with preserved (and mildly reduced) ejection fraction: a comparative review of spironolactone and finerenone

  Hafsa Azam, Syed Sarmad Javaid, Mahir Karakas

  2026-07-06

  https://doi.org/10.4081/cardio.2026.110

  72

  PDF: 36

  HTML: 2

• The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis

  Muhammad Shariq Usman, Arsalan Hamid, Shurjeel Uddin Qazi, Mikhail N. Kosiborod, Deepak L. Bhatt, Muhammad Shahzeb Khan, Muthiah Vaduganathan, Javed Butler

  2024-06-28

  https://doi.org/10.4081/cardio.2024.35

  3645

  PDF: 827

  Conflict of interest: 362

  SUPPLEMENTARY MATERIAL: 314

  HTML: 106

• Advanced cancer as a heart failure like syndrome due to cardiac wasting cardiomyopathy: facts and numbers

  Muhammad Shahzeb Khan, Javed Butler, Laibah Arshad Khan, Markus S. Anker

  2024-12-30

  https://doi.org/10.4081/cardio.2024.58

  3649

  PDF: 700

  HTML: 122

• Beyond trial neutrality: treatment discontinuation and the hidden signal in SPIRIT-HF trial

  Viana Copeland, Andrew J.S. Coats

  2026-03-31

  https://doi.org/10.4081/cardio.2026.100

  1388

  PDF: 382

  HTML: 197

• Demographic and regional trends of heart failure and cachexia-related mortality among older adults in the United States, from 1999 to 2020

  Ishaque Hameed, Muhammad Nashit, Zahra Quettawala Mufaddal, Syed Sarmad Javaid, Muhammad Hanif

  2025-09-19

  https://doi.org/10.4081/cardio.2025.83

  570

  PDF: 337

  HTML: 77

• Hypertension-related heart failure mortality among older adults in the United States: a nationwide analysis of demographic and regional trends

  Muhammad Muneeb Ur Rehman, Muhammad Sameer Arshad, Muhammad Abdul Tawab, Rahael Javaid, Sunil Modi, Marat Fudim

  2026-03-31

  https://doi.org/10.4081/cardio.2026.97

  1358

  PDF: 341

  SUPPLEMENTARY FILES: 244

  HTML: 137

• iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on prevention and treatment of cardiometabolic disease

  Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J.S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuanlin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss Quintana, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed , Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano Ruiz, Nandini Chatterjee, Vijay Chopra, Marc-André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M.C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Yuhui Zhang, Martha Gulati, Naveed Sattar, José Luis Zamorano

  2025-09-30

  https://doi.org/10.4081/cardio.2025.86

  3940

  PDF: 3497

  Supplementary: 412

  Appendix: 356

• The impact of maternal congenital heart disease on pregnancy outcomes in Malta: a retrospective study

  Maryanne Caruana, Miriam Gatt, Oscar Aquilina, Charles Savona Ventura, Victor Grech, Jane Somerville

  2023-12-29

  https://doi.org/10.4081/cardio.2023.14

  1823

  pdf: 228

  HTML: 2

• Lipoprotein(a): what clinicians need to know

  Laibah Arshad Khan, Muhammad Hanif, Ahmed Mustafa Rashid

  2025-09-01

  https://doi.org/10.4081/cardio.2025.80

  1383

  PDF: 1192

  HTML: 36

• Filling the void: digoxin and the first randomized evidence in rheumatic heart disease

  Viana Copeland, Andrew J.S. Coats, Javed Butler, Stefan D. Anker

  2026-07-03

  https://doi.org/10.4081/cardio.2026.108

  110

  PDF: 39

  HTML: 2

• Using multiple primary endpoints in clinical trials with a focus on heart failure

  Stefan D. Anker, Javed Butler, Khawaja M. Talha, Tim Friede

  2024-06-28

  https://doi.org/10.4081/cardio.2024.33

  6311

  PDF: 913

  HTML: 368

• Familial hypercholesterolemia: state-of-the-art

  Ahmed Kamal Siddiqi, Kumail Mustafa Ali, Rameen Shahid, Shamna Haris, Anandita Kulkarni, Iliyan Mithani, Wilhelm Haverkamp, Muhammad Shahzeb Khan

  2026-06-29

  https://doi.org/10.4081/cardio.2026.102

  1364

  PDF: 504

  HTML: 37

• Obesity and left atrial function: state of the art

  Ahmed Mustafa Rashid, Muhammad Shahzeb Khan, Fawaz Alenezi, Stefan D. Anker, Fabian Knebel

  2026-03-31

  https://doi.org/10.4081/cardio.2026.96

  931

  PDF: 325

  HTML: 125

• The impact of frailty on in-hospital outcomes in patients with HFrEF

  Saad Ahmed Waqas, Taimor Mohammed Khan, Ahmed Kamal Siddiqi, Shahzad Hassan, Stefan D. Anker

  2025-12-17

  https://doi.org/10.4081/cardio.2025.88

  654

  PDF: 259

  Supplementary: 94

  HTML: 25

• Advancements in transcatheter tricuspid valve repair and replacement: a state-of-the-art review with echocardiographic outcomes

  Asad Gul Rao, Syed Sarmad Javaid, Ahmed Mustafa Rashid, Fawaz Alenezi

  2025-09-15

  https://doi.org/10.4081/cardio.2025.81

  1353

  PDF: 665

  HTML: 289

• Is the obesity paradox present in left ventricular assist device recipients? A BMI-based analysis

  Saad Ahmed Waqas, Hibah Siddiqui, Faouzi Kallel, Shahzad Hassan

  2025-09-30

  https://doi.org/10.4081/cardio.2025.84

  407

  PDF: 423

  Supplementary: 198

  HTML: 60

• Epidemiology of peripartum cardiomyopathy in Africa

  Kamilu M. Karaye, Abdulrazaq G. Habib, Karen Sliwa

  2024-06-28

  https://doi.org/10.4081/cardio.2024.31

  2802

  PDF: 610

  HTML: 172

• Ten-year survival after indirect mitral annuloplasty with the Carillon Mitral Contour System in functional mitral regurgitation. A single-center followup from the REDUCE-FMR trial

  Janusz Lipiecki, Piotr Kalmucki, Larry E. Miller, Nicolas Durel

  2026-06-26

  https://doi.org/10.4081/cardio.2026.106

  107

  PDF: 38

  HTML: 8

• Quality of life in Maltese adults with congenital heart disease: a second look An APPROACH-IS substudy

  Maryanne Caruana, Philip Moons, Adrienne H. Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Maayke Sluman, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Alexandra Soufi, Edward Callus, Victor Grech, Silke Apers

  2024-03-28

  https://doi.org/10.4081/cardio.2024.26

  2001

  PDF: 244

  HTML: 9

• Intervention options: depression and cardiovascular disease during COVID-19

  Eirini Flouda, Athena Stefanatou, Tinia Apergi

  2023-11-28

  https://doi.org/10.4081/cardio.2023.5

  2038

  pdf: 392

  HTML: 40

• Preliminary study on the immunohistochemical expression of galectin-3 in hypertrophic hearts

  Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo

  2024-06-28

  https://doi.org/10.4081/cardio.2024.37

  1571

  PDF: 431

  HTML: 30
• 

  Importance of patient-reported outcomes in cardiovascular illnesses

  Wardah Rasool, Ahmed Kamal Siddiqi, Laibah Arshad Khan

  2025-06-30

  https://doi.org/10.4081/cardio.2025.69

  2445

  PDF: 589

  HTML: 184

• Aldosterone synthase inhibitors in cardio-renal diseases: a state-of-the-art review

  Muhammad Hamza Dawood, Muhammad Shahzeb Khan, Ahmed Mustafa Rashid, Wilhelm Haverkamp

  2025-12-31

  https://doi.org/10.4081/cardio.2025.91

  955

  PDF: 432

  HTML: 70

• iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025

  Vijay Chopra, Muhammad Shahzeb Khan, Magdy Abdelhamid, William T. Abraham, Offer Amir, Stefan D. Anker, John J. Atherton, Fernando Bacal, Ralph Stephan von Bardeleben, Dulce Brito, Lucrecia Maria Burgos, Javed Butler, Maria Rosa Costanzo, Albertino Damasceno, Justin A. Ezekowitz, Ishaque Hameed, Sivadasanpillai Harikrishnan, Tiny Jaarsma, Anuradha Lala, Ileana L. Piña, Clara Saldarriaga, David Sim, John R. Teerlink, Nqoba Tsabedze, Hiroyuki Tsutsui, Jing Yu, Yuhui Zhang, Mohammad Zubaid, Nikhil Balankhe, Juan Esteban Gomez-Mesa, James L. Januzzi, Marvin Konstam, Rhonda Monroe, Elijah Ogola, Vinayagam Palaniappan, Mark C. Petrie, Fausto J. Pinto, Girish C. Rajadhyaksha, Amina Rakisheva, Carlos E. Ramos, Victor Rossel, Naoki Sato, P. Christian Schulze, Andrew Sindone, Hadi N. Skouri, Harriette G.C. Van Spall, Aistė Štaraitė, Lynne Warner Stevenson, Kadhim Sulaiman, Tzung-Dau Wang, Michael Böhm, Andrew J.S. Coats, Shelley Zieroth

  2025-06-30

  https://doi.org/10.4081/cardio.2025.70

  15497

  PDF: 9108

  Appendix: 1173

• The muscle hypothesis of shortness of breath in patients with cachexia

  Stefan D. Anker, Muhammad Shahzeb Khan, Laibah Arshad Khan, Giuseppe M.C. Rosano, Maurizio Volterrani, Mitja Lainscak, Piotr Ponikowski, Andrew J.S. Coats

  2024-12-30

  https://doi.org/10.4081/cardio.2024.57

  3597

  PDF: 972

  HTML: 50

• Biological plausibility and implications of obesity associated valvular heart diseases

  Francesco Fioretti, Brian R. Lindman, Javed Butler

  2024-11-05

  https://doi.org/10.4081/cardio.2024.49

  2969

  PDF: 916

  HTML: 36

• SGLT2 inhibitors and risk reduction for mortality in high-risk patients: a meta-analysis of randomized controlled trials

  Tariq Jamal Siddiqi, Javed Butler, Andrew J.S. Coats, Subodh Verma, Tim Friede, Gerasimos Filippatos, Stefan D. Anker

  2023-11-23

  https://doi.org/10.4081/cardio.2023.2

  1485

  pdf: 370

  Supplementary Material: 78

  HTML: 214

• Relaxin-2 for heart failure with preserved ejection fraction: a comment on the termination of a phase-II trial investigating the relaxin-2 analogue, LY3540378

  Thomas Bernd Dschietzig, Guy Salama

  2024-12-30

  https://doi.org/10.4081/cardio.2024.56

  4886

  PDF: 1008

  HTML: 122

• To clip or not to clip moderate-to-severe functional mitral regurgitation in patients with heart failure?

  Muhammad Shahzeb Khan, Javed Butler, Tim Friede, Piotr Ponikowski, Stefan D. Anker

  2024-11-05

  https://doi.org/10.4081/cardio.2024.44

  3152

  PDF: 897

  HTML: 39