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Using multiple primary endpoints in clinical trials with a focus on heart failure

Stefan D. Anker, Javed Butler, Khawaja M. Talha, Tim Friede

2024-06-28

https://doi.org/10.4081/cardio.2024.33

5449

PDF: 709

HTML: 160
Clinical trial design, endpoints and regulatory considerations in heart failure

Giuseppe M.C. Rosano

2024-03-28

https://doi.org/10.4081/cardio.2024.18

5616

PDF: 443

HTML: 69
Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial

Stephan von Haehling, Wolfram Doehner, Ruben Evertz, Tania Garfias-Veitl, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, Piotr Ponikowski, Michael Böhm, Tim Friede, Stefan D. Anker

2023-12-27

https://doi.org/10.4081/cardio.2023.15

2471

pdf: 514

HTML: 28
iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on prevention and treatment of cardiometabolic disease

Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J.S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuanlin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss Quintana, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed , Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano Ruiz, Nandini Chatterjee, Vijay Chopra, Marc-André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M.C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Yuhui Zhang, Martha Gulati, Naveed Sattar, José Luis Zamorano

2025-09-30

https://doi.org/10.4081/cardio.2025.86

785

PDF: 2256

Supplementary: 300

Appendix: 249
Sex-based differences in characteristics, management, and outcomes in heart failure with reduced ejection fraction

Christian Basile, Stefan D. Anker, Gianluigi Savarese

2025-06-30

https://doi.org/10.4081/cardio.2025.73

725

PDF: 196

Supplementary: 140

Appendix: 109

HTML: 20
Cardiac wasting in patients with advanced cancer: state of the art review

Laibah Arshad Khan, Muhammad Shahzeb Khan, Rania Usman Latif, Markus S. Anker

2025-04-16

https://doi.org/10.4081/cardio.2025.65

2338

PDF: 430

HTML: 24
To clip or not to clip moderate-to-severe functional mitral regurgitation in patients with heart failure?

Muhammad Shahzeb Khan, Javed Butler, Tim Friede, Piotr Ponikowski, Stefan D. Anker

2024-11-05

https://doi.org/10.4081/cardio.2024.44

2983

PDF: 759

HTML: 14
Is the obesity paradox present in left ventricular assist device recipients? A BMI-based analysis

Saad Ahmed Waqas, Hibah Siddiqui, Faouzi Kallel, Shahzad Hassan

2025-09-30

https://doi.org/10.4081/cardio.2025.84

121

PDF: 204

Supplementary: 142

HTML: 16
New left ventricular thrombus and embolic events in left ventricular dysfunction postmyocardial infarction

Ali A. Youssef, Shaima Al-Omani, Mustafa A. Alrefae, Ahmad Suliman, Reem Hassan, Omar Saleh, Zizi S. Khalifa

2024-11-05

https://doi.org/10.4081/cardio.2024.43

1862

PDF: 656

HTML: 3
Baseline echocardiographic characteristics of patients enrolled in the randomized investigation of MitraClip device in heart failure (RESHAPE HF-2) trial: comparison with COAPT and Mitra-FR

Ralph Stephan von Bardeleben, Muhammad Shahzeb Khan, Martin Geyer, Tim Friede, Javed Butler, Monika Diek, Jutta Heinrich, Marius Placzek, Roberto Ferrari, William T. Abraham, Ottavio Alfieri, Angelo Auricchio, Antoni Bayes-Genis, John G.F. Cleland, Gerasimos Filippatos, Finn Gustafsson, Wilhelm Haverkamp, Malte Kelm, Karl-Heinz Kuck, Ulf Landmesser, Aldo P. Maggioni, Marco Metra, Vlasis Ninios, Mark C. Petrie, Tienush Rassaf, Frank Ruschitzka, Ulrich Schäfer, P. Christian Schulze, Konstantinos Spargias, Alec Vahanian, Jose Luis Zamorano, Andreas Zeiher, Mahir Karakas, Friedrich Koehler, Mitja Lainscak, Alper Öner, Nikolaos Mezilis, Efstratios K. Theofilogiannakos, Ilias Ninios, Michael Chrissoheris, Panagiota Kourkoveli, Konstantinos Papadopoulos, Grzegorz Smolka, Wojciech Wojakowski, Krzysztof Reczuch, Fausto J. Pinto, Łukasz Wiewiórka, Zbigniew Kalarus, Marianna Adamo, Evelyn Santiago-Vacas, Tobias Friedrich Ruf, Michael Gross, Joern Tongers, Gerd Hasenfuß, Wolfgang Schillinger, Piotr Ponikowski, Stefan D. Anker

2024-06-28

https://doi.org/10.4081/cardio.2024.40

5258

PDF: 720

HTML: 22
Optimized heart failure therapy in patients with very advanced cancer in palliative care: dosing strategies from the EMPATICC trial

Markus S. Anker, Sven Bercker, Ulrich Laufs, Michael Böhm, Bela Merkely, Monika Diek, Tim Heise, Martin Hellmich, Marius Placzek, Tim Friede, Stefan D. Anker, Lorenz Lehmann, Ulf Landmesser, Dominik P. Modest, Muhammad Shahzeb Khan, Amir A. Mahabadi, Matthias Totzeck, Mitra Tewes, Muhammad Sameer Arshad, Raluca Mincu, Javed Butler, Ulrich Keller, Johann Ahn, Lars Bullinger, Tienush Rassaf

2025-08-20

https://doi.org/10.4081/cardio.2025.78

304

PDF: 309

Appendix: 196

HTML: 46
Sex differences in clinical characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction

Christian Basile, Stefan D. Anker, Gianluigi Savarese

2025-07-16

https://doi.org/10.4081/cardio.2025.76

734

PDF: 181

Supplementary: 145

Appendix: 104

HTML: 18
Bridging the gap between study outcomes and real-world results. Algorithm-driven management in a rural cardioMEMS population

Marc Atzenhoefer, Elizabeth Dille, Rebecca Steinke, Nicole Weigert, Keri Sabel, Kirsten Rasmussen

2025-04-16

https://doi.org/10.4081/cardio.2025.63

3099

PDF: 615

HTML: 19
The effect of sauna on cardiac and skeletal muscle function in patients with HFpEF (SAUNA-HFpEF): rationale and design

Tarek Bekfani, Kris G. Vargas, Flor Gomez, Alexander Schmeisser, Ruediger C. Braun-Dullaeus

2025-06-30

https://doi.org/10.4081/cardio.2025.67

2067

PDF: 438

HTML: 73
The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis

Muhammad Shariq Usman, Arsalan Hamid, Shurjeel Uddin Qazi, Mikhail N. Kosiborod, Deepak L. Bhatt, Muhammad Shahzeb Khan, Muthiah Vaduganathan, Javed Butler

2024-06-28

https://doi.org/10.4081/cardio.2024.35

2334

PDF: 642

Conflict of interest: 318

SUPPLEMENTARY MATERIAL: 252

HTML: 39
Global Cardiology issue highlights

Andrew J.S. Coats

2024-06-28

https://doi.org/10.4081/cardio.2024.41

3452

PDF: 394

HTML: 0

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Using multiple primary endpoints in clinical trials with a focus on heart failure

Clinical trial design, endpoints and regulatory considerations in heart failure

Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial

iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on prevention and treatment of cardiometabolic disease

Sex-based differences in characteristics, management, and outcomes in heart failure with reduced ejection fraction

Cardiac wasting in patients with advanced cancer: state of the art review

To clip or not to clip moderate-to-severe functional mitral regurgitation in patients with heart failure?

Is the obesity paradox present in left ventricular assist device recipients? A BMI-based analysis

New left ventricular thrombus and embolic events in left ventricular dysfunction postmyocardial infarction

Baseline echocardiographic characteristics of patients enrolled in the randomized investigation of MitraClip device in heart failure (RESHAPE HF-2) trial: comparison with COAPT and Mitra-FR

Optimized heart failure therapy in patients with very advanced cancer in palliative care: dosing strategies from the EMPATICC trial

Sex differences in clinical characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction

Bridging the gap between study outcomes and real-world results. Algorithm-driven management in a rural cardioMEMS population

The effect of sauna on cardiac and skeletal muscle function in patients with HFpEF (SAUNA-HFpEF): rationale and design

The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis

Global Cardiology issue highlights

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