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iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025 - Focus on prevention and treatment of cardiometabolic disease

Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J.S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuanlin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss Quintana, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed , Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano Ruiz, Nandini Chatterjee, Vijay Chopra, Marc-André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M.C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Yuhui Zhang, Martha Gulati, Naveed Sattar, José Luis Zamorano

2025-09-30

https://doi.org/10.4081/cardio.2025.86

1087

PDF: 28

Supplementary: 316

Appendix: 264
Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial

Stephan von Haehling, Wolfram Doehner, Ruben Evertz, Tania Garfias-Veitl, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, Piotr Ponikowski, Michael Böhm, Tim Friede, Stefan D. Anker

2023-12-27

https://doi.org/10.4081/cardio.2023.15

2542

pdf: 560

HTML: 30
Baseline echocardiographic characteristics of patients enrolled in the randomized investigation of MitraClip device in heart failure (RESHAPE HF-2) trial: comparison with COAPT and Mitra-FR

Ralph Stephan von Bardeleben, Muhammad Shahzeb Khan, Martin Geyer, Tim Friede, Javed Butler, Monika Diek, Jutta Heinrich, Marius Placzek, Roberto Ferrari, William T. Abraham, Ottavio Alfieri, Angelo Auricchio, Antoni Bayes-Genis, John G.F. Cleland, Gerasimos Filippatos, Finn Gustafsson, Wilhelm Haverkamp, Malte Kelm, Karl-Heinz Kuck, Ulf Landmesser, Aldo P. Maggioni, Marco Metra, Vlasis Ninios, Mark C. Petrie, Tienush Rassaf, Frank Ruschitzka, Ulrich Schäfer, P. Christian Schulze, Konstantinos Spargias, Alec Vahanian, Jose Luis Zamorano, Andreas Zeiher, Mahir Karakas, Friedrich Koehler, Mitja Lainscak, Alper Öner, Nikolaos Mezilis, Efstratios K. Theofilogiannakos, Ilias Ninios, Michael Chrissoheris, Panagiota Kourkoveli, Konstantinos Papadopoulos, Grzegorz Smolka, Wojciech Wojakowski, Krzysztof Reczuch, Fausto J. Pinto, Łukasz Wiewiórka, Zbigniew Kalarus, Marianna Adamo, Evelyn Santiago-Vacas, Tobias Friedrich Ruf, Michael Gross, Joern Tongers, Gerd Hasenfuß, Wolfgang Schillinger, Piotr Ponikowski, Stefan D. Anker

2024-06-28

https://doi.org/10.4081/cardio.2024.40

5343

PDF: 728

HTML: 29
Advancements in transcatheter tricuspid valve repair and replacement: a state-of-the-art review with echocardiographic outcomes

Asad Gul Rao, Syed Sarmad Javaid, Ahmed Mustafa Rashid, Fawaz Alenezi

2025-09-15

https://doi.org/10.4081/cardio.2025.81

348

PDF: 345

HTML: 123
Optimized heart failure therapy in patients with very advanced cancer in palliative care: dosing strategies from the EMPATICC trial

Markus S. Anker, Sven Bercker, Ulrich Laufs, Michael Böhm, Bela Merkely, Monika Diek, Tim Heise, Martin Hellmich, Marius Placzek, Tim Friede, Stefan D. Anker, Lorenz Lehmann, Ulf Landmesser, Dominik P. Modest, Muhammad Shahzeb Khan, Amir A. Mahabadi, Matthias Totzeck, Mitra Tewes, Muhammad Sameer Arshad, Raluca Mincu, Javed Butler, Ulrich Keller, Johann Ahn, Lars Bullinger, Tienush Rassaf

2025-08-20

https://doi.org/10.4081/cardio.2025.78

374

PDF: 346

Appendix: 208

HTML: 52
Using multiple primary endpoints in clinical trials with a focus on heart failure

Stefan D. Anker, Javed Butler, Khawaja M. Talha, Tim Friede

2024-06-28

https://doi.org/10.4081/cardio.2024.33

5524

PDF: 733

HTML: 195
Cardiac wasting in patients with advanced cancer: state of the art review

Laibah Arshad Khan, Muhammad Shahzeb Khan, Rania Usman Latif, Markus S. Anker

2025-04-16

https://doi.org/10.4081/cardio.2025.65

2414

PDF: 487

HTML: 39
Clinical trial design, endpoints and regulatory considerations in heart failure

Giuseppe M.C. Rosano

2024-03-28

https://doi.org/10.4081/cardio.2024.18

5667

PDF: 457

HTML: 69
Lipoprotein(a): what clinicians need to know

Laibah Arshad Khan, Muhammad Hanif, Ahmed Mustafa Rashid

2025-09-01

https://doi.org/10.4081/cardio.2025.80

322

PDF: 676

HTML: 23
The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis

Muhammad Shariq Usman, Arsalan Hamid, Shurjeel Uddin Qazi, Mikhail N. Kosiborod, Deepak L. Bhatt, Muhammad Shahzeb Khan, Muthiah Vaduganathan, Javed Butler

2024-06-28

https://doi.org/10.4081/cardio.2024.35

2486

PDF: 658

Conflict of interest: 320

SUPPLEMENTARY MATERIAL: 256

HTML: 62
Sex differences in clinical characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction

Christian Basile, Stefan D. Anker, Gianluigi Savarese

2025-07-16

https://doi.org/10.4081/cardio.2025.76

778

PDF: 194

Supplementary: 151

Appendix: 105

HTML: 37
Iron supplementation in heart failure and iron deficiency: does it help?

Laibah Arshad Khan, Syed Sarmad Javaid, Javed Butler

2025-09-30

https://doi.org/10.4081/cardio.2025.82

225

PDF: 295

HTML: 49
Importance of patient-reported outcomes in cardiovascular illnesses

Wardah Rasool, Ahmed Kamal Siddiqi, Laibah Arshad Khan

2025-06-30

https://doi.org/10.4081/cardio.2025.69

1975

PDF: 423

HTML: 106
Defining iron replete status in patients with heart failure treated with intravenous iron

Khawaja M. Talha, Javed Butler, Stephan von Haehling, Mitja Lainscak, Piotr Ponikowski, Stefan D. Anker

2023-12-21

https://doi.org/10.4081/cardio.2023.17

2967

pdf: 314

HTML: 53
Sex-based differences in characteristics, management, and outcomes in heart failure with reduced ejection fraction

Christian Basile, Stefan D. Anker, Gianluigi Savarese

2025-06-30

https://doi.org/10.4081/cardio.2025.73

764

PDF: 216

Supplementary: 142

Appendix: 111

HTML: 33
The scientific targets: the myocardium, the vasculature and the body’s response to heart failure

Rafael Vidal-Pérez, Ewa A. Jankowska

2024-03-28

https://doi.org/10.4081/cardio.2024.19

2674

PDF: 206

HTML: 21
To clip or not to clip moderate-to-severe functional mitral regurgitation in patients with heart failure?

Muhammad Shahzeb Khan, Javed Butler, Tim Friede, Piotr Ponikowski, Stefan D. Anker

2024-11-05

https://doi.org/10.4081/cardio.2024.44

3008

PDF: 772

HTML: 17
Rationale and design for the peripartum cardiomyopathy in Nigeria (PEACE) registry

Kamilu M. Karaye, Idris Y. Mohammed, Okechukwu S. Ogah, Basil N. Okeahialam

2023-11-28

https://doi.org/10.4081/cardio.2023.4

1000

pdf: 229

HTML: 44
Bridging the gap: integrating stress echocardiography, iFR, CFR, and FFR in the evaluation of coronary artery disease

Konstantinos Stamos, Theodora Delaporta, Antonios Delaportas

2025-04-16

https://doi.org/10.4081/cardio.2025.66

1294

PDF: 284

HTML: 0
Prognostic factors and outcome in patients submitted into coronary artery bypass surgery with total arterial myocardial revascularization

Elias Tassoulas, Dimitrios Tasoulas, Christos Papaconstantinou, Ioannis Chlorogiannis

2024-12-30

https://doi.org/10.4081/cardio.2024.46

2635

PDF: 451

HTML: 20
Modulation of cardiac metabolism in heart failure

Giuseppe M.C. Rosano, Andrew J.S. Coats

2024-11-05

https://doi.org/10.4081/cardio.2024.30

2350

PDF: 1148

HTML: 26
The association of iron deficiency with right ventricular dysfunction in Africans with heart failure

Adeseye A. Akintunde, Sope T. Orugun

2024-12-30

https://doi.org/10.4081/cardio.2024.53

2306

PDF: 392

Appendix B: 436

Appendix A: 318

HTML: 2
Impella vs intra-aortic balloon pump in patients with acute myocardial infarction complicated with cardiogenic shock: an updated systematic review and meta-analysis

Muhammad Ahmed, Serish Bano, Mutahira Asif, F.N.U. Sidra, Meva Ram, Shahida Bibi

2025-04-16

https://doi.org/10.4081/cardio.2025.61

3319

PDF: 724

Supplementary: 379

HTML: 0
The impact of frailty on in-hospital outcomes in patients with HFrEF

Saad Ahmed Waqas, Taimor Mohammed Khan, Ahmed Kamal Siddiqi, Shahzad Hassan, Stefan D. Anker

2025-12-17

https://doi.org/10.4081/cardio.2025.88

131

PDF: 51

Supplementary: 10

HTML: 1
Coronary artery calcium scoring. What clinicians need to know

Syeda Sundus Shah Bokharii, Cristiana Vitale, Eman Khan, Giuseppe M.C. Rosano, Laibah Arshad Khan

2025-12-11

https://doi.org/10.4081/cardio.2025.87

364

PDF: 160

HTML: 2
Bridging the gap between study outcomes and real-world results. Algorithm-driven management in a rural cardioMEMS population

Marc Atzenhoefer, Elizabeth Dille, Rebecca Steinke, Nicole Weigert, Keri Sabel, Kirsten Rasmussen

2025-04-16

https://doi.org/10.4081/cardio.2025.63

3140

PDF: 638

HTML: 19
Acute interventional management of spontaneous coronary artery dissection: case series and literature review

Enrico Cerrato, Ilaria Meynet, Giorgio Quadri, Federico Giacobbe, Cristina Rolfo, Francesco Tomassini, Fabio Ferrari, Fabio Mariani, Luca Lo Savio, Matteo Bianco, Paola Destefanis, Alessia Luciano, Carol Gravinese, Emanuele Tizzani, Sara Giolitto, Antonella Corleto, Fabrizio D’Ascenzo, Umberto Barbero, Fernando Macaya, Javier Escaned, Roberto Pozzi, Ferdinando Varbella

2024-03-28

https://doi.org/10.4081/cardio.2024.22

3884

PDF: 180

HTML: 39
Intervention options: depression and cardiovascular disease during COVID-19

Eirini Flouda, Athena Stefanatou, Tinia Apergi

2023-11-28

https://doi.org/10.4081/cardio.2023.5

1797

pdf: 247

HTML: 21
The effect of sauna on cardiac and skeletal muscle function in patients with HFpEF (SAUNA-HFpEF): rationale and design

Tarek Bekfani, Kris G. Vargas, Flor Gomez, Alexander Schmeisser, Ruediger C. Braun-Dullaeus

2025-06-30

https://doi.org/10.4081/cardio.2025.67

2149

PDF: 469

HTML: 100
New left ventricular thrombus and embolic events in left ventricular dysfunction postmyocardial infarction

Ali A. Youssef, Shaima Al-Omani, Mustafa A. Alrefae, Ahmad Suliman, Reem Hassan, Omar Saleh, Zizi S. Khalifa

2024-11-05

https://doi.org/10.4081/cardio.2024.43

1902

PDF: 679

HTML: 3
Is the obesity paradox present in left ventricular assist device recipients? A BMI-based analysis

Saad Ahmed Waqas, Hibah Siddiqui, Faouzi Kallel, Shahzad Hassan

2025-09-30

https://doi.org/10.4081/cardio.2025.84

183

PDF: 232

Supplementary: 147

HTML: 21
SGLT2 inhibitors and risk reduction for mortality in high-risk patients: a meta-analysis of randomized controlled trials

Tariq Jamal Siddiqi, Javed Butler, Andrew J.S. Coats, Subodh Verma, Tim Friede, Gerasimos Filippatos, Stefan D. Anker

2023-11-23

https://doi.org/10.4081/cardio.2023.2

1116

pdf: 244

Supplementary Material: 40

HTML: 121
Preliminary study on the immunohistochemical expression of galectin-3 in hypertrophic hearts

Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo

2024-06-28

https://doi.org/10.4081/cardio.2024.37

1320

PDF: 326

HTML: 12
Relaxin-2 for heart failure with preserved ejection fraction: a comment on the termination of a phase-II trial investigating the relaxin-2 analogue, LY3540378

Thomas Bernd Dschietzig, Guy Salama

2024-12-30

https://doi.org/10.4081/cardio.2024.56

3980

PDF: 912

HTML: 81
Exercise capacity, iron deficiency and depressive symptoms in patients with asymptomatic chronic systolic heart failure

Sven Christopher Aland, Christoph Gertler, Hannah Leonie Bräunig, Timo Schröder, Frank Edelmann, Rolf Wachter, Christoph Herrmann-Lingen, Gerd Hasenfuß, Anja Sandek

2024-06-28

https://doi.org/10.4081/cardio.2024.39

1521

PDF: 454

HTML: 4
Global Cardiology issue highlights

Andrew J.S. Coats

2024-06-28

https://doi.org/10.4081/cardio.2024.41

3469

PDF: 400

HTML: 0
Evolving targets for heart failure: the journey so far

Giuseppe M.C. Rosano, Jerneja Farkas

2023-11-28

https://doi.org/10.4081/cardio.2023.6

2036

pdf: 327

HTML: 4
Treatment pathways in patients with heart failure with preserved ejection fraction and obesity: perspectives from cardiology specialists and patients

Javed Butler, Sanjiv J. Shah, Melissa Magwire, Carlos Campos, Muhammad Shariq Usman, Anthony Hoovler, Anup Sabharwal, Barry A. Borlaug

2024-06-28

https://doi.org/10.4081/cardio.2024.38

1928

PDF: 519

SUPPLEMENTARY MATERIAL: 301

GRAPHICAL ABSTRACT: 265

HTML: 27
The muscle hypothesis of shortness of breath in patients with cachexia

Stefan D. Anker, Muhammad Shahzeb Khan, Laibah Arshad Khan, Giuseppe M.C. Rosano, Maurizio Volterrani, Mitja Lainscak, Piotr Ponikowski, Andrew J.S. Coats

2024-12-30

https://doi.org/10.4081/cardio.2024.57

2502

PDF: 685

HTML: 9
Effect of metformin and empagliflozin on myocardial function in insulin-resistant patients with heart failure: rationale and design of the METRIS-HF-DZHK18 Trial

Wolfram Doehner, Tim Friede, Frank Edelmann, Ulf Landmesser, Sebastian Winkler, Burkert Pieske, Fabian Knebel, Sebastian Kelle, Diethelm Tschöpe, Antje Meyer, Nadja Jauert, Marius Placzek, Jeanette Schulz-Menger, Stephan von Haehling, Stefan D. Anker

2025-12-31

https://doi.org/10.4081/cardio.2025.89

79

PDF: 24

Appendix: 6
Adherence to lifestyle therapy in patients with chronic heart failure and comorbidity

Elena Efremova, Alexander Shutov

2023-12-20

https://doi.org/10.4081/cardio.2023.8

1221

pdf: 256

HTML: 25
Demographic and regional trends of heart failure and cachexia-related mortality among older adults in the United States, from 1999 to 2020

Ishaque Hameed, Muhammad Nashit, Zahra Quettawala Mufaddal, Syed Sarmad Javaid, Muhammad Hanif

2025-09-19

https://doi.org/10.4081/cardio.2025.83

204

PDF: 198

HTML: 32
Safety and efficacy of left atrial appendage closure in cancer versus non-cancer patients: a systematic review and meta-analysis

Muhammad Ahmed, Fatima Muskan, Mohsin Zaheer, Manesh Kumar, Sawera Gul, Abdul Hadi Ansari, Muhammad Sameer Jamal, Muhammad Sohaib Asghar, M. Chadi Alraies, Shiny Teja Kolli, Praveen Kumar Komminni, Priya Hotwani, Vishal Reddy Bejugam

2025-06-30

https://doi.org/10.4081/cardio.2025.72

1115

PDF: 261

Supplementary: 159

HTML: 89
Large language models to write scientific manuscripts: to be considered but not trusted

Christian Basile, Stefan D. Anker, Gianluigi Savarese

2025-06-30

https://doi.org/10.4081/cardio.2025.74

762

PDF: 216

HTML: 5
Aortic valve replacement in asymptomatic severe aortic stenosis. A focused review

Aimen Shafiq, Rohan Dev Trehan, Mitja Lainscak, Sanjeev Trehan

2025-12-31

https://doi.org/10.4081/cardio.2025.93

46

PDF: 15
The impact of diurnal fasting during Ramadan on patients with established cardiac disease: a systematic review

Marwan M. Refaat, Nadim El Jamal, Hebah M. El-Rayess, Anthony Gebran, Amar M. Salam

2024-06-28

https://doi.org/10.4081/cardio.2024.32

2356

PDF: 817

HTML: 15

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